Showing posts with label Development. Show all posts
Showing posts with label Development. Show all posts

Tuesday, April 1, 2014

Baby Brain Scans Predict Later Cognitive Development?

The shape of a newborn baby’s brain can predict its later cognitive development, according to a new study from New York neuroscientists Marisa Spann and colleagues.

Here’s the paper: Morphological features of the neonatal brain support development of subsequent cognitive, language, and motor abilities

Now, while the word ‘phrenology‘ gets banded around a lot these days by people who don’t like neuroscience, this study actually sort of fits that description – except instead of ‘bumps on skulls’ it was more ‘bumps on brains’. The authors scanned 48 babies (within 6 weeks of birth) using MRI to obtain an image of brain structure; they then analyzed the shape of each brain using a deformation-based morphology approach.

This revealed areas on each brain that were bigger or smaller than the average newborn brain:

neonates_brain

The outputs were a set of local ‘indentations’ and ‘protrusions’… or, one might say, troughs and bumps? Anyway, after being scanned, the babies were followed up for two years and tested every 6 months to measure their developmental functioning in the domains of motor, language, and cognitive skills (using the Bayley-III scale.)

There were significant correlations between brain shape and later development, however interestingly, most of these were negative correlations – that is, infants with a thinner cerebral cortex in each particular area did better:

cognition_vs_brain

Here for example you can see results for the cognitive domain at ages 6, 12, 18 and 24 months. There are correlations in many areas, mostly negative (purple blobs), with the exception of some positive (yellow) correlations in the occipital cortex but these areas only predicted performance at 6 months.

So it would seem that in general, ‘less is more’ for many parts of the newborn brain. Which is interesting because in a previous study, as the authors write,

At birth, head circumference as a proxy for brain volume was the strongest (positive) predictor of intelligence at 4 years (Gale et al 2006).

Spann et al don’t seem to have analyzed whole-brain volume, but why would regional cortical thickness be a negative predictor of development? They suggest that it might be a slow-and-steady-wins-the-race type deal:

Slower or more protracted maturation of the brain or brain subregions, that are otherwise growing rapidly specifically in the neonatal period, may support the development and emergence of improved motor, language, and cognitive abilities in later infancy.

However… the sample size wasn’t huge. Although they scanned 48 babies, only 37 had usable MRI data (for the other 11, quality was too poor). And of those, they were only able to get developmental assessments on n=33 at age 6 months, falling to n=18 by 24 months. A decently sized study at the outset, it had become a decidedly small one by the end.

And I do worry (as I always seem to these days) about head movement. It’s hard enough to get adults to lie still in an MRI scanner. With babies it’s all but impossible which is why the authors used the special motion-resistant T2 PROPELLER sequence. However, they still had to throw out about a quarter of their scans, perhaps for excessive motion.

Could the scans they included have been degraded by movement, perhaps correlated with baby temperament and later behaviour, and could this have confounded the deformation-based morphology? Spann et al say that “the similarity transformation of an infant brain to a template is robust to the presence of noise in the imaging data” but it would have been nice to see some quantitative checks of that assumption.

ResearchBlogging.orgSpann, M., Bansal, R., Rosen, T., & Peterson, B. (2014). Morphological features of the neonatal brain support development of subsequent cognitive, language, and motor abilities Human Brain Mapping DOI: 10.1002/hbm.22487

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Thursday, October 31, 2013

International Business Development Executive


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Business Development & Administration Assistant: 6 to 12 month Internship

Logo: Cedar Consulting Apply directly

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SalaryPaidAdditional salary infoThe successful candidate will receive between £16,000 - £20,000 pro rata salary. ContractFixed termWorking hoursFull-timeNumber of vacancies1Start dateWinterClosing date11/11/2013 LocationGreater LondonFull location detailsWC1H 8BB

This is a new position for a Business Development (BD) assistant within the Cedar Consulting team based in our Kings Cross office, London. Reporting directly to the BD Manager the successful candidate will work on and help drive a variety of marketing, business development and communications projects targeting existing customers, new prospects and key partners. This internship will be for 6 to 12 months with the opportunity to apply for a full time position at the end of the period. This is a varied role and key tasks that the successful candidate should expect to be involved in include (but are not limited to):

- Working closely with Oracle and the BD Manager to promote customer focused events such as dinners and seminars.

- Help prepare and manage exhibition stands at select industry shows.

- Help with the execution of marketing campaigns.

- Help increase our social media impact.

- Assist in market analysis.

- Undertake general marketing support for the sales effort.

- Bring fresh ideas to the team.

- Developing marketing collateral.

- Assisting with admin tasks in other parts of the business.

You will need to have

- An honourable work ethic.

- A good university degree, preferably in one of the following key areas: Marketing, Event Management, Business or Social Media. We will also consider candidates with other degrees who can demonstrate the relevant skills and experience.

- A strong interest and ideally experience in Event Management and/or working on promotions.

- The flexibility to work independently or as part of a team.

- Excellent verbal and written communication skills.

- Working experience in Microsoft office suite - particularly Word, XL and Outlook.

- Confidence on the phone.

- Good time management and proven track record of working to deadlines.

- The flexibility to work occasionally outside the usual business hours to complete certain tasks.

- A passion, energy and drive to be successful.

- Permission to work in the UK and Europe.

It would be desirable if you have

- Experience of working in a marketing team in a B2B environment.

- Interest in the Information Technology market place.

- Business Development Experience.

- B2B Social Media experience.

- CRM system experience.

- Clean driving license.

About Cedar Consulting

Cedar Consulting is an established software services consultancy and has been in existence for over 18 years. With offices across the globe it has an enviable client base including many blue chip companies, United Nations agencies and other large non-profit organisations. As one of Oracle’s key partners for both PeopleSoft and Fusion projects, Cedar Consulting is privileged to work across all business sectors. Driving our success is a joint Oracle and Cedar Consulting events and marketing programme going back over 10 years. At the heart of our business are our people, we aim provide a great environment to further a career and develop new skills.

Please apply with your resume and a supporting covering letter. Deadline for applicants is the 11th November.


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Friday, October 25, 2013

LLAMA webinar helps you create a leadership development training

CHICAGO — If you have ever thought about how to create a leadership development training for your region or institution, LLAMA’s new webinar may be what you need.  The Library Leadership and Management Association (LLAMA) will present “Creating a Leadership Development Training” from 1:30 to 3 p.m. Central time on Wednesday, Nov. 20. This webinar will present the process used to create the Virginia Library Leadership Academy, a biennial leadership development training program for library staff in Virginia sponsored by the Virginia Library Association.  Participants will have a checklist of points to review should they wish to develop a training program in their region.

Who should attend: library staff interested in starting a leadership development training program; members of state library associations

By the end of this webinar participants will:

know what points to consider if they wish to create their own leadership development training program;have tools for determining how viable a program like this could be in their region;what to consider regarding training format: face-to-face, webinar, combination;how to determine the location for an on-site training;how to select or hire training facilitators and consultants;know what is involved in preparing the budget along with some suggestions for getting financial support.

Presenters:

Elizabeth Hensley is the founding chair of the Leadership Development Forum (LDF) of the Virginia Library Association.

Nan Carmack is the director of the Campbell County Virginia Public Library System.  She is chair of the Leadership Development Forum and is a graduate of the Virginia Library Leadership Academy (VALLA).

M. Teresa Doherty is the head, Information Services at Virginia Commonwealth University Libraries.  She is the coordinator for the Spring 2014 Virginia Library Leadership Academy and is a 2010 VALLA graduate.

Fees:
LLAMA member: $49
Non-LLAMA member $59
LLAMA group rate (5 or more people at one site) $199
Non-LLAMA group rate (5 or more people at one site) $239

Register online: http://tinyurl.com/3zhtecm

Register with a purchase order or by mail: registration form (PDF).

For questions about this webinar or other LLAMA programs, contact Fred Reuland. freuland@ala.org

About the Library Leadership and Management Association
The Library Leadership and Management Association (www.ala.org/llama) advances outstanding leadership and management practices in library and information services by encouraging and nurturing individual excellence in current and aspiring library leaders. LLAMA is a division of the American Library Association.


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Thursday, June 13, 2013

Vitamin D deficiency may be a factor in development of allergies

THE QUESTION Too little Vitamin D can lead to bone problems and diseases. Might it also play a role in the development of allergies?

THIS STUDY analyzed data on 6,590 people, roughly half of them 21 years of age and younger and half older. The group was deemed representative of the U.S. population. Vitamin D levels were determined by blood tests, as was sensitivity to 17 common allergens. Among the youths, food and environmental allergies were greater in those with lower levels of Vitamin D. Young people deficient in Vitamin D were about twice as likely as those with higher levels of the nutrient to have peanut or ragweed allergies and nearly five times as likely to be allergic to oak. Allergies to dogs, cockroaches, shrimp, ryegrass, Bermuda grass, birch, certain fungi and thistle also were more common in youths with the lowest Vitamin D levels. In adults, however, no link was found between Vitamin D levels and allergen sensitivity.

WHO MAY BE AFFECTED? People with low levels of Vitamin D. For most people, exposure to 15 minutes of sunshine three times a week enables the body to produce a sufficient amount of Vitamin D. It's also available in some foods (dairy products and fortified cereals, for example) and in supplements. The amount needed varies by age, with current guidelines suggesting that people need 600 international units (IU) daily up to age 70 and 800 IU thereafter. Some experts, though, say those amounts are not sufficient.

CAVEATS The study did not test whether increasing Vitamin D levels through supplements or other means would affect allergy symptoms, nor did it determine why the association found in children was not replicated among the adults.

FIND THIS STUDY Feb. 17 online issue of the Journal of Allergy and Clinical Immunology (www.jacionline.org/inpress).

LEARN MORE ABOUT Vitamin D at www.hsph.harvard.edu/nutritionsource and www.ods.od.nih.gov.

- Linda Searing

The research described in Quick Study comes from credible, peer-reviewed journals. Nonetheless, conclusive evidence about a treatment's effectiveness is rarely found in a single study. Anyone considering changing or beginning treatment of any kind should consult with a physician.


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Tuesday, April 23, 2013

Juno: A Look Back at Successful Development

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Jupiter Graphic

Dr. Scott Bolton, Juno’s principal investigator from the Southwest Research Institute, and the Juno team had been working toward this milestone for several years. A mission of this length and complexity required careful planning and testing to increase its chances of success. Everyone felt a great sense of accomplishment when, shortly after separating from the Centaur upper stage, the spacecraft deployed its large solar arrays as planned and began its journey to Jupiter.

The second mission in NASA’s New Frontiers Program, Juno experienced an unusually long definition and planning phase—described by Juno’s first project manager, Rick Grammier, in ASK Magazine’s Spring 2008 issue—that gave us several advantages, including “more time to talk.” This proved beneficial for a distributed team that included members from the Jet Propulsion Laboratory (JPL), Lockheed Martin, Goddard Space Flight Center, Southwest Research Institute, the Applied Physics Laboratory, University of Iowa, Malin Space Science Systems, the Italian Space Agency (ASI), and others. We were able to establish strong working relationships and excellent communication by having regular status telecons, workshops, and frequent in-person meetings.

These relationships helped tremendously during our risk-mitigation planning efforts, which included integrating instruments early on; working through issues such as the impact the L’Aquila, Italy, earthquake had on the Ka-band translator development; developing fallback options for Juno’s system-level environmental tests; and using an innovative tool to track our schedule margin.

Early in the implementation phase, the Juno team performed interface tests at the Lockheed Martin facility between the engineering models (early versions of hardware) of each instrument’s electronics and the spacecraft’s flight-like hardware. These early integrations helped find and fix hardware and software bugs in the interfaces, increasing the likelihood that flight-instrument integrations would proceed more smoothly.

Concerned about the possible late deliveries of the avionics and solar arrays, we also prepared a set of fallback options that gave us some flexibility for completing the tests successfully.

The first set of tests in spring 2009 between the instruments’ engineering models and the Data, Telemetry, and Command Interface (DTCI) Engineering Development Unit (EDU) board focused on confirming the compatibility of the commanding, engineering telemetry, low-speed science data, and high-speed science data hardware interfaces. These tests uncovered some issues early—such as the clock polarity coming out of the DTCI being inverted—and gave us confidence to move forward with the spacecraft and instrument flight builds. A side benefit was the establishment of an excellent working relationship between the instrument teams and the Lockheed Martin software, simulation, and instrument-integration team members, which was helpful throughout the implementation phase.

During the first part of 2010, instrument engineering models were sent to the Lockheed Martin facility’s System Test Lab for a second round of tests that focused on confirming higher-level functionality in the flight-software interface. Greg Bollendonk, the flight software lead, accelerated the development of the instrument-interface portions of the spacecraft flight software in order to deliver beta versions for these tests. Another goal was to flow data to each instrument’s ground-support equipment—as would be done during the assembly, test, and launch operations (ATLO) phase—to enable the instrument teams to become familiar with the data formats and ATLO processes. At the time, the spacecraft field-programmable gate arrays that controlled the instrument interfaces were not yet mature, so they benefited from this early testing as well.

More issues were uncovered and corrected, including significant ones in the high-speed data interface that required several months to resolve. One issue in this interface involved the spacecraft’s memory-management software. This spacecraft flight software wasn’t saving the highest-quality data for the ultraviolet spectrograph (UVS) instrument. The flight software team took advantage of the UVS engineering model in the System Test Lab to iterate code changes with remote support from the instrument team (located at Southwest Research Institute) until the problem was resolved. All in all, this risk mitigation program paid off in smoother flight-instrument integrations during ATLO.

New Frontiers Program Office Insight and Participation

By Brian Key

Juno benefited greatly from an extended definition and planning phase that gave the project team “more time to talk." This additional time also allowed the New Frontiers Program office to become more familiar with the mission definition and to independently assess the project's planning activities. Understanding schedule and technical risks prior to confirmation also allowed the program office to develop a representative cost risk that could be carried as an unallocated future expense (UFE) by the Science Mission Directorate (SMD), and could be included in the overall life-cycle cost for the project at confirmation. This cost risk was established not only through understanding risks but also by examining previous mission performance histories to determine the soundness of the mission cost and schedule profiles.

Upon confirmation, NASA established a principal investigator cost cap and an overall project cost cap. Throughout implementation, the principal investigator (PI) and project manager managed to the tighter PI cost cap. allocations from the SMD-held UFE were controlled through a process established by the program office, which required the project to formally request a UFE allocation and provide a rationale for the request. The program office would evaluate this request and provide the Planetary Science Division (PSD) New Frontiers program executive with an assessment and recommendation.

Essential to this process was the well-established communication among the project, program office, and PSD. Open and candid communication and information flow between the project and program office mission manager gave all levels of NASA management a good understanding of the project's status. This communication and information came in many forms, from monthly status meetings to weekly tag-ups to daily test status e-mails, intertwined with frequent, impromptu teleconferences.

As the project developed and implemented early risk mitigations, worked around impacts from natural disasters, and developed and executed alternate test flows and configurations due to component, instrument, or subsystem delays, these developments were communicated effectively and efficiently to the program office mission manager and PSD New Frontiers program executive.

ASI contributed two instruments to Juno’s payload: the Jovian infrared auroral mapper (JIRAM) and the Ka-band translator for the gravity science investigation. These contributions, added during the definition and planning phase, were not part of the original mission proposal. The ASI contribution gave us an alternate supplier for the Ka-band translator in the original proposal while the JIRAM instrument was completely new. One key feature of this arrangement was that neither of these contributions were required in order for Juno to satisfy its mission success criteria.

This decoupling helped when a magnitude 5.8 earthquake in L’Aquila, Italy, in April 2009 severely damaged the Thales Alenia Space plant where the Ka-band translator’s engineering model was being built. This natural disaster threw its development into disarray. Initially, the team had no idea what the impact would be on the model’s delivery, scheduled to happen by June 2009, or on the flight unit’s delivery scheduled for December 2009.

Rick Nybakken, Juno’s deputy project manager and the prime project interface with ASI, led the development of a recovery plan that upgraded the engineering model to a flight quality unit (called the flyable engineering model, or FEM), enabling one unit to meet both delivery requirements. This higher-risk approach was acceptable because full performance from the Ka-band translator was not required for Juno to meet its success criteria. A flight unit would still be built and tested, and if it became available soon enough, we would consider it for flight. The FEM was delivered and installed in April 2010. When the flight unit became available in August 2010, we replaced the FEM with the flight unit due to its higher reliability and because we could still accommodate a swap at that late date.

Working through this difficult situation was helped by the excellent rapport that Scott, Rick, Dorothy Lewis (Ka-band translator cognizant engineer), and the project team had with ASI and Thales Alenia Space. Quarterly meetings helped foster this relationship. Rick had seen this model used successfully on the Cassini mission and set up a rotation of a core set of Juno personnel, both management and technical, that would travel to Italy every three months for management and technical discussions. The ASI/Thales Alenia team traveled to JPL occasionally for the same purpose.

The relationships established proved to be very useful when we worked with ASI and Thales Alenia to recover from the earthquake. The team worked closely with Roberto Formaro, ASI program manager for Juno, to align the project and ASI strategies for revised delivery requirements and tactical interactions with Thales Alenia. All Thales Alenia customers who had been affected by the earthquake were claiming priority in the recovery planning, but Juno’s only option to receive a flyable Ka-band translator in time for launch was to develop and implement a coordinated strategy among Juno, ASI, and Thales Alenia. Establishing a successful path forward might not have been possible without the meetings and resulting relationships established during the early part of development.

The system-level environmental test suite is a major test activity every spacecraft experiences during the ATLO phase. Its purpose is to subject the spacecraft to the environments it will experience during its mission. These environments include the vibration of launch (simulated by an acoustic test), the shock of separation from the launch vehicle, the spacecraft’s electromagnetic self-compatibility at launch and during science-data gathering, and the temperature in the vacuum of deep space that the spacecraft will experience on its trajectory to Jupiter. The Juno team planned a traditional set of tests involving the flight hardware and flight software and presented that baseline at the environmental test readiness review (ETRR).

Concerned about possible late deliveries of the avionics and solar arrays, we also prepared a set of fallback options that gave us some flexibility for completing the tests successfully. These options outlined the minimum set of hardware required for each test, including the required pedigree (flight or non-flight). For example, flight-like engineering models could be used for the self-compatibility tests if the flight avionics were not available, and the solar-array qualification model could be used for the shock test if the solar arrays had not yet been delivered. We also outlined specific vibration-level and thermal-cycle tests that would need to be executed to ensure the complete environmental qualification of the spacecraft if a flight-hardware component had to be reworked post-test. Preparing these fallback options ahead of time helped clarify and align our thinking for these anomalous situations.

These options were also presented at the ETRR and discussed openly with the review board. This up-front review minimized the management coordination the project needed later on when some of the options had to be implemented to complete the environmental tests within schedule.

Tim Halbrook, the Lockheed Martin ATLO manager, used typical schedule tools to track Juno’s progress: a sixteen-month ATLO flow updated monthly, a thirty-day Gantt chart updated weekly, and a seven-day Gantt chart updated daily. To plan and track the use of Juno’s sixty days of ATLO schedule margin, however, Tim also developed a Corridor plot (see figure at top of page). On the Corridor plot, the curve of schedule margin burndown—the rate at which margin is used up—corresponded with the margin days sprinkled strategically throughout the ATLO flow. Tim also included a second curve on the plot that was offset by 20 percent below the nominal curve. Juno’s actual schedule margin use was plotted weekly on the same figure.

If our actual margin burndown remained between these two curves, we did not need to take action. But if it dropped below the 20 percent margin erosion curve, Tim would schedule second shifts and/or weekend shifts to bring the actual burndown back within the corridor. Shortly after ATLO started, unplanned troubleshooting and rework with both the avionics and telecom hardware dropped the schedule margin close to the 20 percent margin erosion curve. We recovered schedule margin by using additional shifts once the issues had been worked through successfully.

This graphic became a handy visual tool for the whole team to monitor the schedule margin and to make decisions regarding resource control. It also enabled Juno managers and external managers to tell at a glance how ATLO was progressing.

Throughout Juno’s implementation phase, management teams at all levels looked for ways to help development proceed more smoothly and with lower risk, and the team as a whole worked through many challenges successfully. This was possible due to our strong working relationships and excellent communication, enhanced by the close communicative style of our project leaders. The result meant completing Juno on time and on budget, and its excellent flight performance so far shows the benefits of our efforts.

Note: This work was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. © California Institute of Technology. Government sponsorship acknowledged.



Jan Chodas

Jan Chodas is currently the project manager for the Juno mission in the New Frontiers Program. Prior to this position, she served at the Jet Propulsion Laboratory in numerous roles, including manager of the Systems and Software Division, assistant flight system manager for the Mars Exploration Rover project, flight system manager for the Space Interferometry Mission, project element manager for the Cassini attitude and articulation control subsystem, and technical manager for the Galileo attitude and articulation control subsystem.


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