Showing posts with label molecules. Show all posts
Showing posts with label molecules. Show all posts

Thursday, April 18, 2013

New technique for cooling molecules may be stepping stone to quantum computing

Eric Hudson. Credit: Reed Hutchinson

(Phys.org) —The next generation of computers promises far greater power and faster processing speeds than today's silicon-based based machines. These "quantum computers"—so called because they would harness the unique quantum mechanical properties of atomic particles—could draw their computing power from a collection of super-cooled molecules.

But chilling molecules to a fraction of a degree above absolute zero, the temperature at which they can be manipulated to store and transmit data, has proven to be a difficult challenge for scientists.

Now, UCLA physicists have pioneered a new technique that combines two traditional atomic cooling technologies and brings normally springy molecules to a frozen standstill. Their research is published March 28 in the journal Nature.

"Scientists have been trying to cool molecules for a decade and have succeeded with only a few special molecules," said Eric Hudson, a UCLA assistant professor of physics and the paper's senior author. "Our technique is a completely different approach to the problem—it is a lot easier to implement than the other techniques and should work with hundreds of different molecules."

Previous attempts to create ultracold molecules were only effective with one or two specific kinds. Creating a method that can be used with many different molecules would be a major step forward because it is difficult to say which materials might be used in quantum computers or other future applications, Hudson said.

By immersing charged barium chloride molecules in an ultracold cloud of calcium atoms, Hudson and his colleagues are able to prevent most of the molecules from vibrating and rotating. Halting the molecules is a necessary hurdle to overcome before they can be used to store information like a traditional computer does.

"The goal is to build a computer that doesn't work with zeros and ones, but with quantum mechanical objects," Hudson said. "A quantum computer could crack any code created by a classical computer and transmit information perfectly securely."

Hudson's experiment makes molecules extremely cold under highly controlled conditions to reveal the quantum mechanical properties that are hidden under normal circumstances. At room temperature, molecules rocket around, bouncing into each other and exchanging energy. Any information a scientist attempted to store in such a chaotic system would quickly become gibberish.

"We isolate these molecular systems in a vacuum, effectively levitating them in the middle of nothing," Hudson said. "This removes them from the rest of the world that wants to make them classical."

The quantum mechanical world of subatomic particles deviates from the classical world that we observe with the naked eye because according to quantum mechanics, electrons can only exist at specific energy levels. In a quantum computer made of a collection of single atoms, information might be stored by boosting some atomic electrons to higher energy levels while leaving others at lower energy states. However, these atomic energy states are not stable enough to reliably preserve data, Hudson said.

"One of the challenges with atoms is that their energy states are very easily influenced by the outside world," Hudson said. "You make this beautiful quantum state, but then the outside world tries to destroy that information."

Instead of saving data in easily disrupted atomic energy states, a more robust way to store information is in the rotational energy states of molecules, Hudson said. A spinning molecule in the lowest energy rotational state could represent a binary one, while a stationary molecule could represent a binary zero.

Despite applications for quantum computing and other industries, cooling molecules to extremely low temperatures has proved a challenge. Even the simplest molecule composed of only two atoms is a far more complex system than a single atom. Each molecule vibrates and rotates like a miniature whirling slinky, and all of that movement must be stilled so that the molecule can lose energy and cool down.

A new cooling technique

To solve the ultracold molecule conundrum, Hudson and his group first created a floating cloud of calcium atoms corralled by incoming laser beams from all directions. This magneto-optical trap keeps the atoms stationary as it cools them to nearly absolute zero. They then use specialized rods with high, oscillating voltages as part of an ion trap to confine a cloud of positively-charged barium chloride molecules within the ultracold ball of calcium atoms to complete the cooling process.

For the vibrating, energetic molecules to lose heat, they must spend a significant amount of time in contact with the surrounding ultracold atom cloud. Hudson and his colleagues used barium chloride ions, molecules missing one electron, because charged molecules are easier to trap and cool than their neutral counterparts. The use of molecular ions is an essential innovation because previous efforts have demonstrated that neutral molecules ricochet off ultracold atoms without sufficient heat transfer.

"When a molecular ion and a neutral atom get close together they get in tight and bang off each other a bunch before the ion goes away," Hudson said. "When they collide like that it is very easy for the energy in one to go to the other."

While magneto-optical and ion traps are not new to the world of molecular physics, Hudson and his colleagues became the first group to combine these methods to create a cloud of ultracold molecules. This paper is the result of over four years of work spent designing, building, and testing their experiment.

"These two different technologies earned Nobel prizes for the scientists who developed them, but there wasn't really a body of knowledge about how to put these two procedures together," Hudson said.

More information: The research is funded by the Army Research Office and the National Science Foundation.

Journal reference: Nature search and more info website

Provided by University of California, Los Angeles search and more info website


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Wednesday, April 10, 2013

Build­ing mol­e­cules: Serendipity pays off

Upper and lower left: Green spots indicate carbon atoms known to undergo reactions. Right panel: Purple spot indicates a carbon atom thought not to undergo reactions. The team discovered, using accelerated serendipity, a way to cause this carbon to react, resulting in addition of functional groups, and potentially leading to new drugs or other important industrial chemicals. Credit: Science

Serendipity – the act of finding something good or useful while not specifically searching for it – can sometimes pay off. Now Princeton University chemistry researchers report that this non-specific type of searching has yielded a new method of building molecules for use in new drugs, new agricultural chemicals and even new perfumes.

In a paper published today in the journal Science, Princeton's David MacMillan and his team describe the discovery of a new chemical reaction – not noted before in nature or in any lab – that could assist pharmaceutical chemists and others who routinely create new chemicals for a variety of industries.

Until now, no one realized this chemical reaction – which involves adding atoms to a specific carbon atom on a molecule – could occur, according to MacMillan, the James S. McDonnell Distinguished University Professor of Chemistry at Princeton. "If you show this chemical reaction to most chemists, they immediately say 'that's impossible,'" MacMillan said.

In this case, the team discovered this "impossible" reaction using an approach MacMillan pioneered that he calls "accelerated serendipity." The researchers use robotic arms to conduct thousands of reactions per day by combining in test tubes different combinations of chemicals along with catalysts that spur the reactions. When the investigators find a reaction that makes an interesting product, they study it to understand how the reaction occurs.

"We didn't invent this new reaction – nature did that," MacMillan said, "but we figured out how to get the reaction to happen in the lab." said MacMillan. His team, which included graduate student Michael Pirnot, postdoctoral researcher David Martin and former postdoctoral researcher Danica Rankic, uses ordinary light bulbs as catalysts, a technique developed in MacMillan's lab and published in Science in 2008, to spur the reactions.

Going forward, chemists can add this new reaction to their tool box of methods for building up molecules, which they do in a way analogous to joining together pieces of Kinex or Tinker Toys, by swapping in new parts to increase the function of the molecule. In the new reaction published today, the team discovered a way to join so-called "functional groups" to a specific carbon atom (see diagram) in larger structures known as ketones and aldehydes. The ability to add functional groups to that carbon atom was thought impossible until now.

This new chemical reaction has wide applications, MacMillan said. "This is a fundamental reaction which any chemist can start using."

For example, a chemist who is building a drug to treat Alzheimer's disease might desire to add a chemical group to the reluctant carbon atom. Normally that would require the chemist to conduct several different chemical reactions over several weeks, but with the new reaction the chemist could build the drug in two days and be testing drug candidates much more quickly.

Similarly a chemist at a fragrance company could use the new reaction to experiment with the creation of new perfume formulations.

MacMillan's original paper on accelerated serendipity, published in 2011 in Science, successfully discovered a reaction now used in the drug industry. Yet it was controversial because other scientists interpreted the robotic searches as random searches, when in fact they were not random. "We chose chemicals that had never been shown to react with each other – those are the ones we believe might lead to as-yet undiscovered reactions." MacMillan said that these reactions may have been created in the past by chemists who didn't recognize what they were.

More information: Pirnot, M. et al. Photoredox Activation for the Direct ß-Arylation of Ketones and Aldehydes. Science 29 March 2013. Vol. 339 no. 6127 pp. 1593–1596. www.sciencemag.org/content/339/6127/1593.abstract

Journal reference: Science search and more info website

Provided by Princeton University search and more info website


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